This book presents the latest breakthroughs in mammary gland transgenesis: The exploitation of transgenetic technology for the production of therapeutic proteins by routine or conventional methods. Following an overview of all relevant mathodologies, readers will easily find relevant information on the regulation of milk gene expression and bioreactor species such as cattle, rabbits, and pigs.
This book presents the latest in mammary gland transgenesis, the exploitation of transgenic technology for the production of therapeutic proteins by routine or conventional methods. Following a section with an overview of all relevant methodologies, readers will find relevant information on the regulation of milk gene expression and bioreactor species such as cattle, rabbits and pigs.
1. The Mammary Gland as a Bioreactor: A Personal Perspective.- 2. Introducing Genetic Information into Mammalian Embryos.- 3. The Factors of Tissue-Specific Expression of the Bovine ?-Casein Gene.- 4. Casein Gene-Based Mammary Gland-Specific Transgene Expression.- 5. Regulation of the Betalactoglobulin and Whey Acidic Protein Genes.- 6. Selection of Genes for Expression in Milk: The Case of the Human Erythropoietin Gene.- 7. Transgenesis in Rabbits.- 8. Transgenic Pigs as Bioreactors For Therapeutic Proteins.- 9. Transgenic Livestock as Bioreactors.- 10. Transgenic Dairy Cattle.- 11. Trying to Glimpse the Future.